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Recombinant Ovine Growth Hormone Binding Protein

Synonyms     GHR, GHBP, GH receptor, Somatotropin receptor. 
Introduction    GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized. 
Description     Growth Hormone Binding Protein Ovine Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 28 kDa.
GHBP is purified by proprietary chromatographic techniques. 
Source     Escherichia Coli. 
Physical Appearance     Sterile Filtered White lyophilized (freeze-dried) powder. 
Formulation     GHBP was lyophilized from a concentrated (1mg/ml) solution with 0.0045mM NaHCO3. 
Solubility     It is recommended to reconstitute the lyophilized Growth Hormone Binding Protein in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. 
Stability      Lyophilized Growth Hormone Binding Protein although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GHBP should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles. 
Purity     Greater than 95.0% as determined by:
(a) Analysis by SEC-HPLC.
(b) Analysis by SDS-PAGE. 
Amino acid sequence     The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Phe-Ser-Gly-Ser. 
Usage      CHI's products are furnished for LABORATORY RESEARCH USE ONLY.They may not be used as drugs,agricultural or pesticidal products, food additives or household chemicals. 

Cat No. Description Unit Price Order
7-00520 Recombinant Ovine Growth Hormone Binding Protein 5 µg $ 103.17 
7-00521 Recombinant Ovine Growth Hormone Binding Protein 20 µg $ 268.25 
7-00522 Recombinant Ovine Growth Hormone Binding Protein 1 mg $ 6400.00 
Ordering Information
Email:order@chiscientific.com
Tel:800.986.6008
Fax:978.897.5462
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