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Recombinant Ovine Prolactin Soluble Receptor

Synonyms     PRL-R, PRLR, OPR, PRLrI.
Introduction     Prolactin is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. The initial step in its action is the binding to a specific membrane receptor (prolactin receptor) which belongs to the superfamily of class 1 cytokine receptors. The function of the prolactin receptor is mediated, at least in part, by two families of signaling molecules: Janus kinases and signal transducers and activators of transcription. Prolactin (PRL) is a hormone involved in a variety of important functions including ion transport and osmoregulation, stimulation of milk, protein synthesis as well as the regulation of numerous reproductive functions. PRL exerts its influence on different cell types through a signal transduction pathway which begins with the binding of the hormone to a transmembrane PRL receptor. Immunoreactive PRL receptor, a member of the cytokine receptor family, varies in size (short and long forms) with tissue source and species, from ~40 kDa to 100 kDa. The PRL receptor consists of at least three separate domains: an extracellular region with 5 cysteines which contains the prolactin binding site, a single transmembrane domain and a cytoplasmic region, the length of which appears to influence ligand binding and regulate cellular function.
Description     Prolactin Receptor Ovine Extra Celleular Domain Recombinant ?produced in E.Coli is a non-glycosylated, Polypeptide chain containing 213 amino acids and having a molecular mass of 24.4 kDa.
The Prolactin Receptor is purified by proprietary chromatographic techniques.
Source     Escherichia Coli.
Physical Appearance     Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation     The protein was lyophilized from a concentrated (1mg/ml) solution with 0.0045mM NaHCO3.
Solubility     It is recommended to reconstitute the lyophilized PRL-R in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability     Lyophilized PRL-R although stable at room temperature for 3 weeks, should be stored desiccated below -18℃. Upon reconstitution Prolactin Receptor should be stored at 4℃ between 2-7 days and for future use below -18℃.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
Purity     Greater than 97.0% as determined by:
(a) Analysis by SEC-HPLC.
(b) Analysis by SDS-PAGE.
Amino acid sequence     The sequence of the first five N-terminal amino acids was determined and was found to be Gln-Ser-Pro-Pro-Glu.
Protein content     Protein quantitation was carried out by two independent methodsUV spectroscopy at 280 nm using the absorbency value of 2.78 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics).
Usage     CHI's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Cat No. Description Unit Price Order
7-01438 Recombinant Ovine Prolactin Soluble Receptor 5 µg $ 103.17 
7-01439 Recombinant Ovine Prolactin Soluble Receptor 20 µg $ 268.25 
7-01440 Recombinant Ovine Prolactin Soluble Receptor 1 mg $ 6400.00 
Ordering Information
Email:order@chiscientific.com
Tel:800.986.6008
Fax:978.897.5462
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